JUPITER, Fla., Aug. 22, 2018 /PRNewswire/ — Jupiter Orphan Therapeutics, Inc. (“JOT”), Jupiter, FL, today announced that it has received new data regarding an increase in mitochondrial biogenesis in liver and brain from a recently performed study in a frequently studied Alzheimer’s disease animal model, the triple transgenic (APPsw / PS1M146V / TauP301L) mouse.
Daily oral treatment, 50mg/kg, of mice for 5 weeks resulted in a marked increase of liver (72%) and brain (30%) mitochondrial DNA in JOTROL™ treated mice compared to vehicle controls. JOTROL™ induced similar increases of the mitochondrial genes Nd1 and Rnr1 and no change in the nuclear gene NEB. Our results with JOTROL™ are in line with a growing body of literature showing that select polyphenolic compounds, notably high doses of resveratrol, exert direct effects on mitochondrial ultra-structure and function. In other words, treatment with JOTROL™ will increase the effectiveness of the cell’s mitochondrial machinery. Resveratrol, the active component of JOTROL™, is in fact sometimes referred to as a mitochondrial “nutrient.”